TETRAETHYLTHIURAM DISULFIDE

PRODUCT IDENTIFICATION
CAS NO. 97-77-8

TETRAETHYLTHIURAM DISULFIDE

EINECS NO. 202-607-8
FORMULA [(C2H5)2NCS2-]2
MOL WT. 296.54

H.S. CODE

 2930.30

TOXICITY

 Oral, rat: LD50 : 500 mg/kg
SYNONYMS Disulfiram; Tetidis; Teturam; Thioscabin; TETD; Disulfuram;
Tetraethylthioperoxydicarbonothioic Diamide; Tetraethylthiuram; Disulfan; Bis((diethylamino)thioxomethyl)disulfide; Bis(N,N-diethylthiocarbamoyl) Disulfide; 1,1'-Dithiobis(N,N-diethylthioformamide); N,N,N',N'-tetraethylthiuram Disulfide;

SMILES

 N(C(SSC(N(CC)CC)=S)=S)(CC)CC

CLASSIFICATION

Vulcanization accelerator, Thiuram

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE

off-white powder granules

MELTING POINT

 64 C
BOILING POINT 117 c
SPECIFIC GRAVITY 1.31

SOLUBILITY IN WATER

Slightly soluble (4.09 mg/l at 25 C)

VAPOR DENSITY  
AUTOIGNITION

 

pKa (Dissociation Constant at 20 C)
log Pow 3.88 (Octanol-water)
VAPOR PRESSURE 8.70E-04 (mmHg at 25 C)
HENRY'S LAW 8.32E-05 (atm-m3/mole at 25 C)
OH RATE 3.92E-10 (cm3/molecule-sec at 25 C Atmospheric )

REFRACTIVE INDEX

 

NFPA RATINGS

Health: 2, Flammability: 1, Reactivity: 0

FLASH POINT

 

STABILITY Stable under ordinary conditions

GENERAL DESCRIPTION & APPLICATIONS

Some pharmaceutical grade of thiocarbamate derivatives such as Disulfiram are used in the treatments of chronic alcoholism by inhibiting aldehyde dehydrogenase, a breakdown product of alcohol, to accumulate in the blood.. Disulfiram is also being studied as a treatment for cocaine dependence, as it prevents the breakdown of dopamine and several studies have reported that it has anti-protozoal activity as well. It is a peptizing agent in sulfur-modified polychloroprenes. Thiocarbamate compounds such as Ziram and Zineb are also used as a fungicide, seed disinfectant, bactericide and insecticide.

This compound is used as a primary and secondary accelerator or as a sulfur donor in most sulfur-cured elastomers in rubber industry.
SALES SPECIFICATION

APPEARANCE

off white powder

ASSAY

99.0% min

MELTING POINT

64 C (Initial), 69 -73 C (Final)

SIEVE ANALYSIS

0.1% max (+ 150 µm)

HEAT LOSS

0.3% max

ASH

0.3% max

TRANSPORTATION
PACKING 25kgs in Bag
HAZARD CLASS  
UN NO.  
GENERAL DESCRIPTION OF ACCELERATOR
Sulfur combines with nearly all elements. Sulfur forms ring and chain structures as it is the second only to carbon in exhibiting catenation. The 8-membered ring and shorter chain structure of sulfur molecule is important in vulcanization process which individual polymers are linked to other polymer molecules by atomic bridges. This process produces thermoset materials which are cross-linked and irreversible substances. The term thermoplastic is for high molecular weight polymers which can undergo melting-freezing cycle. Thermosets are not melted and re-molded on heating after cured. The split of sulfur 8-membered ring structure into shorter chains provides rubber vulcanization process. The split are liked with cure sites (some of the solid bonds in the molecule) on rubber molecules, resulting in forming sulfur bridges typically between 2 and 10 atoms long. Vulcanization makes rubber harder, more durable and more resistant to heating, aging and chemical attacks. The number of sulfur atoms in the sulfur bridges varies physical properties of the end products. Short bridges containing one or two sulfur atoms offer heat resistance and long bridges offer flexible property. Vulcanization can also be accomplished with certain peroxides, gamma radiation, and several other organic compounds. The principal classes of peroxide cross-linking agents are dialkyl and diaralkyl peroxides, peroxyketals and peroxyesters. Other vulcanizing agents include amine compounds for the cross-linking of fluorocarbon rubbers, metal oxides for chlorine-containing rubbers (notably zinc oxide for chloroprene rubber) and phenol-formaldehyde resins for the production of heat-resistant butyl rubber vulcanizates. Accelerator, in the rubber industry, is added with a curing agent to speed the vulcanization. Accelerators contain sulfur and nitrogen like derivatives of benzothiazole and thiocarbanilides. The popular accelerators are sulfenamides (as a delayed-action accelerators), thiazoles, thiuram sulfides, dithocarbamates and guanidines.

There are some types of rubber accelerators. They are used in combination with each other in accordance with vulcanizing and/or acid-base conditions. Some examples classified by chemical structure are as below;

  • Thiazole
    • 2-Mercaptobenzothiazole (CAS #: 149-30-4)
    • Dibenzothiazole disulfide (CAS #: 120-78-5)
    • 2-Mercaptobenzothiazole Zinc salt (CAS #: 155-04-4)
  • Sulphenamide
    • N-Cyclohexyl-2-benzothiazole sulfenamide (CAS #: 95-33-0)
    • N-Oxydienthylene-2-benzothiazole sulfenamide (CAS #: 102-77-2)
    • N-tert-butyl-2-benzothiazyl sulfenamide (CAS #: 95-31-8)
  • Guanidine
    • Diphenyl guanidine (CAS #: 102-06-7)
    • Di-o-tolylguanidine (CAS #: 97-39-2)
  • Thiuram
    • Tetramethyl thiuram disulfide (CAS #: 137-26-8)
    • Tetraethyl thiuram disulfide (CAS #: 97-77-8)
    • Tetramethyl thiuram monosulfide (CAS #: 97-74-5)
    • Isobutyl thiuram disulfide (CAS #: 3064-73-1)
    • Tetrabenzylthiuram disulfide (CAS #: 10591-85-2)
    • Dipentamethylene thiuramtetrasulfide (CAS #: 120-54-7)
  • Dithiocarbamate
    • Zinc dimethyl dithiocarbamate (CAS #: 137-30-4)
    • Zinc diethyl dithiocarbamate (CAS #: 14324-55-1)
    • Zinc dibutyl dithiocarbamate (CAS #: 136-23-2)
    • Zinc N-ethyl-dithiocarbamate (CAS #: 14634-93-6)
    • Zinc dibenzyl dithiocarbamate (CAS #: 14726-36-4)
    • Copper dimethyl dithiocarbamate (CAS #: 137-29-1)
  • Thiourea
    • Ethylene thiourea (CAS #: 96-45-7)
    • N,N'-Diethylthiourea (CAS #: 105-55-5)
    • N-N'-Diphenylthiourea (CAS #: 102-08-9)